CAS: | 1229236-86-5 |
分子式: | C23H25ClFN7O |
分子量: | 469.94 |
纯度: | >98% |
溶解性: | DMSO |
存储: | Powder -20℃ 3 years; 4℃ 2 years In solvent -80℃ 6 months;-20℃ 1 month |
研究领域: | Cancer |
Target: | JAK2, 3 nM (IC50); FGFR2, 32 nM (IC50); Flt-4, 25 nM (IC50); Tyk2, 44 nM (IC50); JAK3, 48 nM (IC50); FGFR3, 106 nM (IC50); KDR, 109 nM (IC50); FLT3, 4 nM (IC50); TRKB, 95 nM (IC50); ALK, 138 nM (IC50) |
描述: | Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM. Gandotinib (LY2784544) also inhibits FLT3, FLT4, FGFR2, TYK2, and TRKB with IC50 of 4, 25, 32, 44, and 95 nM. |