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Tr-PEG8-OH
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tr-PEG8-OH图片
CAS NO:1144113-16-5
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Tr-PEG8-OH 是一种不可降解 (non-cleavable) 的含 8 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Tr-PEG8-OH是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。
Cas No.1144113-16-5
分子式C35H48O9
分子量612.75
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tr-PEG8-OH is a non-cleavable 8 unit PEGADClinker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Adam M. Wawro, et al. Multigram chromatography-free synthesis of octa(ethylene glycol) p-toluenesulfonate. ORGANIC CHEMISTRY. 2016 Jul.
[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.