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Catharanthine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Catharanthine图片
CAS NO:2468-21-5
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
20mg电议

产品介绍
Catharanthine 是一种从马达加斯加长春花中分离出来的生物碱，抑制电压操作的 L 型 Ca2+ 通道，具有抗癌和降血压活性。
Cas No.2468-21-5
别名长春质碱; (+)-3,4-Didehydrocoronaridine
化学名(6R,6aR,9S)-methyl 7-ethyl-6,6a,9,10,12,13-hexahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6-carboxylate
Canonical SMILESO=C([C@@]1(C(N([H])C2=C([H])C([H])=C([H])C([H])=C32)=C3C([H])([H])C4([H])[H])[C@](C(C([H])([H])C([H])([H])[H])=C5[H])([H])N4C([H])([H])[C@@]5([H])C1([H])[H])OC([H])([H])[H]
分子式C21H24N2O2
分子量336.42
溶解度≥ 16.821mg/mL in DMSO
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Catharanthine is an alkaloid isolated from Madagascar periwinkle, inhibits voltage-operated L-type Ca2+ channel, with anti-cancer and blood pressure-lowering activity[1].

References:
[1]. Jadhav A, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345(3):383-92.