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CTPI-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CTPI-2图片
CAS NO:68003-38-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
CTPI-2 是第三代线粒体柠檬酸盐载体 SLC25A1 抑制剂,KD 为 3.5 μM。
Cas No.68003-38-3
别名2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸
化学名2-((4-chloro-3-nitrophenyl)sulfonamido)benzoic acid
分子式C13H9CIN2O6S
分子量356.74
溶解度DMSO:125 mg/mL(350.40 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo; disrupts self-renewal and sphere-forming capacity of the indicated tumor cells relative to monolayer cultures, demonstrates broad activity on lung CSCs, inhibiting mitochondrial respiratory activity, self-renewal and matrix invasion; inhibits tumor growth in in vivo models of NSCLC.

Reference:
[1]. Fernandez HR, et al. Cell Death Differ. 2018 Jul;25(7):1239-1258.