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Fructosyl-lysine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fructosyl-lysine图片
CAS NO:21291-40-7
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Fructosyl-lysine (Fructoselysine) 是葡萄糖与赖氨酸通过美拉德反应生成的一种氨基糖基化产物 (amadori glycation)。Fructosyl-lysine 是葡萄糖烷的前体,葡萄糖烷是一种赖氨酸-精氨酸蛋白交联物,可作为糖尿病中检测的指标。
Cas No.21291-40-7
别名果糖-赖氨酸; Fructoselysine
Canonical SMILESN[C@H](C(O)=O)CCCCNCC([C@@H](O)[C@H](O)[C@H](O)CO)=O
分子式C12H24N2O7
分子量308.33
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine-arginine protein cross-link that can be an indicator in diabetes detection[1].

Fructosyl-lysine (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [14C]fructoselysine to anionic products suggesting the existence of a fructoselysine-kinase activity in E .coli extracts[2].Fructosyl-lysine (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in E .coli extracts[2].Fructosyl-lysine (25 mM; 25 hours) lets E. coli growth at a rate of about one-third of that observed with glucose as a carbon source. Lysine itself does not support growth in the absence of other carbon source and does not affect the growth observed with glucose[2].

Fructosyl-lysine and AGE residues is increased markedly in glomeruli, retina, sciatic nerve, and plasma protein in diabetic rats[1].

[1]. Rabbani N, et al. Hidden complexities in the measurement of fructosyl-lysine and advanced glycation end products for risk prediction of vascular complications of diabetes. Diabetes. 2015 Jan;64(1):9-11. [2]. Karachalias N, et al. Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. Biochem Soc Trans. 2003 Dec;31(Pt 6):1423-5.