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FAPy-adenine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FAPy-adenine图片
CAS NO:5122-36-1
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
FAPy-adenine 是一种氧化的 DNA 碱基。FAPy-adenine 在阿尔茨海默病脑中呈上升趋势。氧化核苷是肿瘤、衰老和神经退行性疾病的生化标志物。
Cas No.5122-36-1
别名4,6-二氨基-5-甲酰胺基嘧啶
Canonical SMILESO=CNC1=C(N)N=CN=C1N
分子式C5H7N5O
分子量153.14
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].

In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine[1].

The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease[1].

[1]. Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. [2]. Cysewski P, et al. Theoretical description of the coding potential of diamino-5-formamidopyrimidines. Z Naturforsch C J Biosci. 1999 Mar-Apr;54(3-4):239-45. [3]. Lee SH, et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18(9):973-7.