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Siomycin A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Siomycin A图片
CAS NO:12656-09-6
包装:500μg
市场价:4672元

产品介绍
Siomycin A 是一种硫肽抗生素，是 Forkhead box M1(FOXM1) 选择性抑制剂，不会影响 Forkhead box 家族的其他成员。 Siomycin A 具有抗肿瘤和促进细胞凋亡的作用。
Cas No.12656-09-6
别名盐霉素 A
Canonical SMILESO=C(NC(C(NC(C(N[C@@H](C)C(N[C@@]1(CCC(C2=NC(C(NC(C(NC(C(N)=O)=C)=O)=C)=O)=CS2)=N[C@]1([H])C3=CSC4=N3)C5=NC(C(NC(C(N/C(C6=NC(C(N[C@@](C7=NC8=CS7)([H])[C@@]([C@H](O)C)(O)C)=O)CS6)=C\C)=O)[C@H](O)C)=O)=CS5)=O)=O)=C)=O)=C)[C@H](C(C)C)NC9C(O)C%10=NC(C(O[C
分子式C71H81N19O18S5
分子量1648.9
溶解度DMF: Soluble,DMSO: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Siomycin A is a peptide thiazole antibiotic, first isolated from S. sioyaensis, that interacts with the 23S rRNA of bacteria. It inhibits FoxM1 (IC50 = ~5 μM), preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, siomycin A prevents proliferation and induces apoptosis in certain types of stem cells as well as cancer cells.