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SI-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SI-2图片
CAS NO:380537-35-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍

SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3).

Cas No.380537-35-9
化学名(1E)-1-(2-pyridinyl)-ethanone-2-(1-methyl-1H-benzimidazol-2-yl)hydrazone
Canonical SMILESC/C(C1=NC=CC=C1)=N\NC2=NC3=C(C=CC=C3)N2C
分子式C15H15N5
分子量265.3
溶解度20mg/mL in ethanol, 30mg/mL in DMSO or DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3). It has been shown to selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct physical interactions with SRC-3.1 SI-2 induces death in various breast cancer cells with IC50 values of 3-20 nM without affecting normal cell viability.[1] At 2 mg/kg, SI-2 can also inhibit primary tumor growth and reduce SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model.[1]

Reference:
[1]. Song, X., Chen, J., Zhao, M., et al. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proceedings of the National Academy of Sciences of the United States of America 113(18), 4970-4975 (2016).