TC-E 5001 是一种 Wnt 通路抑制剂，通过新的腺苷口袋结合抑制 tankyrase 1/2 (TNKS1/2)，Kd 分别为 79 nM 和 28 nM。 TC-E 5001 还抑制 Axin2 和 STF，IC50 分别为 0.709 μM 和 0.215 μM。
| Cas No. | 865565-29-3 |
| 化学名 | 3-(4-methoxyphenyl)-5-(((4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl)thio)methyl)-1,2,4-oxadiazole |
| Canonical SMILES | CC(N1C(C=C2)=CC=C2OC)=NN=C1SCC3=NC(C(C=C4)=CC=C4OC)=NO3 |
| 分子式 | C20H19N5O3S |
| 分子量 | 409.46 |
| 溶解度 | <40.95mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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