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HSP27 inhibitor J2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HSP27 inhibitor J2图片
CAS NO:2133499-85-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
HSP27 inhibitor J2 (J2) 是一种 HSP27 抑制剂,其显著诱导异常 HSP27 二聚体形成并抑制 HSP27 巨聚合物的产生,从而具有抑制 HSP27 的伴侣功能和降低其细胞保护功能的作用。HSP27 inhibitor J2 (J2) 显著增强 17-AAG 的抗增殖活性,并对顺铂诱导的肺癌细胞生长抑制具有敏感性。
Cas No.2133499-85-9
别名J2
Canonical SMILESO=C1C=C(C)OC2=C1C(O)=CC(OCC3SC3)=C2
分子式C13H12O4S
分子量264.3
溶解度DMSO: 25 mg/mL (94.59 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].

[1]. Hwang SY, et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shockprotein 27. Eur J Med Chem. 2017 Oct 20;139:892-900. [2]. Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives.