CAS NO: | 62218-08-0 |
包装 | 价格(元) |
500μg | 电议 |
1mg | 电议 |
Cas No. | 62218-08-0 |
别名 | epsilon-Viniferin |
Canonical SMILES | OC1=CC(/C=C/C2=CC=C(O)C=C2)=C3C(O[C@@H](C4=CC=C(O)C=C4)[C@@H]3C5=CC(O)=CC(O)=C5)=C1 |
分子式 | C28H22O6 |
分子量 | 454.5 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | trans-ε-Viniferin is a stilbene polyphenol and dimer of trans-resveratrol that has been found in various red wines and has diverse biological activities.1,2,3,4,5 It induces disaggregation of aggregated amyloid-β (1-42) fibrils in a cell-free assay and decreases Aβ42- and IL-1β-induced release of TNF-α and IL-6 in primary mouse neuron and astrocyte cocultures.2 trans-ε-Viniferin reduces cytotoxicity induced by truncated huntingtin (Htt) in PC12 cells (EC50 = 30 nM).3 It also reduces production of reactive oxygen species (ROS), mitochondrial dysfunction, and PGC-1α depletion and increases protein levels and deacetylase activity of sirtuin 3 (SIRT3) in cells expressing mutant Htt. trans-ε-Viniferin inhibits calcium-activated chloride channel currents in HT-29 cells (IC50 = ~1 μM).4 In vivo, trans-ε-viniferin (2 μg per animal) reduces rotavirus-induced secretory diarrhea in mice without affecting the rotaviral infection. Dietary administration of trans-ε-viniferin reduces hepatic triglyceride accumulation and body weight increases in a mouse model of diet-induced obesity.5 References |