| CAS： | 880813-36-5 |
| 分子式： | C16H18N2 |
| 分子量： | 238.33 |
| 纯度： | >98% |
| 溶解性： | H2O : < 0.1 mg/mL (insoluble); DMSO : 130 mg/mL (545.46 mM; Need ultrasonic) |
| 存储： | Powder -20℃ 3 years; 4℃ 2 years In solvent -80℃ 6 months;-20℃ 1 month |
| 研究领域： | Cancer |
| Target： | Kd: 167 μM (p53-Y220C)[1], 150 μM (p53Y220C, in Ln229 cells) |
| 描述： | PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, and a relative binding affinity (Kd) of 150 μM in Ln229 cells. |
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