| CAS： | 908112-43-6 |
| 分子式： | C23H27F3N4O3 |
| 分子量： | 464.48 |
| 纯度： | ≥98% |
| 溶解性： | DMSO |
| 存储： | Powder -20℃ 3 years; 4℃ 2 years In solvent -80℃ 6 months;-20℃ 1 month |
| 研究领域： | Cancer |
| Target： | IC50: 10 nM (Her-2)[1], 30 nM (Hsp90 α), 30 nM (Hsp90 β), 4.275 μM (Grp94), 0.862 μM (Trap-1)[2]Kd: 16 nM (Hsp90)[1] |
| 描述： | SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM for Hsp90 and IC50 of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC50 of |
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