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Thiarabine(OSI-7836)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thiarabine(OSI-7836)图片
CAS NO:26599-17-7
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
Thiarabine (OSI-7836) (OSI-7836) 显示出有效的抗肿瘤活性和对 DNA 合成的抑制作用。
Cas No.26599-17-7
别名OSI-7836
Canonical SMILESO[C@H]1[C@H](O)[C@@H](CO)S[C@H]1N2C=CC(N)=NC2=O
分子式C9H13N3O4S
分子量259.28
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thiarabine (OSI-7836) shows potent anti-tumor activity and inhibition of DNA synthesis.

Thiarabine has demonstrated exceptional antitumor activity against numerous human tumor xenografts in mice, being superior to gemcitabine, clofarabine, or cytarabine. Unlike cytarabine, Thiarabine demonstrates excellent activity against solid tumor xenografts, suggesting that this agent has the kind of robust activity in animal models that leads to clinical utility. Thiarabine is effective orally (bioavailability of approximately 16%) and with once per day dosing: Two characteristics that distinguish it from cytarabine. Although both the structure and basic mechanism of action of Thiarabine are similar to that of cytarabine, there are many quantitative differences in the biochemical pharmacology of these two agents that can explain the superior antitumor activity of Thiarabine. Two important attributes are the long retention time of the 5'-triphosphate of thiarabine in tumor cells and its potent inhibition of DNA synthesis. The biochemical pharmacology of Thiarabine is also different from that of gemcitabine[1].

[1]. Parker WB, et al. Thiarabine, 1-(4-Thio-β-D-arabinofuranosyl)cytosine. A Deoxycytidine Analog With Excellent Anticancer Activity. Curr Med Chem. 2015;22(34):3881-96.