| CAS NO: | 161058-83-9 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 161058-83-9 |
| 别名 | O6-(Cyclohexylmethyl)guanine |
| Canonical SMILES | NC1=NC(OCC2CCCCC2)=C3NC=NC3=N1 |
| 分子式 | C12H17N5O |
| 分子量 | 247.3 |
| 溶解度 | DMSO : ≥ 32 mg/mL (129.40 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | NU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1.IC50 value: 17uM (CDK2), 26uM (CDK1)Target: CDKin vitro: NU2058 is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 3 uM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors. References: |
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