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Madrasin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Madrasin图片
CAS NO:374913-63-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Madrasin (DDD00107587) 是一种剪接抑制剂,可在体外阻止剪接中间体和产物的形成,并干扰剪接体组装途径中的一个或多个早期步骤。 Madrasin 还可以在体外抑制 pre-mRNA 剪接,并修饰细胞内内源性 pre-mRNA 的剪接。
Cas No.374913-63-0
别名DDD00107587
Canonical SMILESO=C1N=C(NC2=NC(C)=C3C=CC(OC)=CC3=N2)NC(C)=C1C
分子式C16H17N5O2
分子量311.34
溶解度DMF: 1 mg/ml,DMF:PBS (pH7.2) (1:40): 0.025 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.

References:
[1]. Andrea Pawellek et al. Identification of Small Molecule Inhibitors of Pre-mRNA Splicing. J Biol Chem, 2014 Dec 12, 289(50): 34683-34698.