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LY3177833
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY3177833图片
CAS NO:1627696-51-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
LY3177833 是一种 CDC7 和 pMCM2 抑制剂,IC50 值分别为 3.3 nM 和 290 nM。
Cas No.1627696-51-8
Canonical SMILESO=C1N[C@@](C)(C2=NC=NC=C2F)C3=C1C=C(C4=CNN=C4)C=C3
分子式C16H12FN5O
分子量309.3
溶解度DMSO : ≥ 30 mg/mL (96.99 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LY3177833 is a CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively[1].

LY3177833 (Compound example 4; 10.4-31.2 mg/kg; oral gavage; twice a day; for 2 weeks; female athymic Balb/c nude mice with SW620 cells) treatment causes significant tumor regression in a dosedependent manner. Also, no significant tumor growth is observed for 2 weeks after dosing cessation[1].

References:
[1]. DALLY, Robert Dean, et al. CDC7 Inhibitors. 18 September 2014. WO2014143601A1.