PD 407824 是一种检查点激酶 Chk1 和 WEE1 抑制剂，IC50 分别为 47 和 97 nM。
| Cas No. | 622864-54-4 |
| 化学名 | 9-hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione |
| Canonical SMILES | O=C1NC(C2=C1C(C(C=C(O)C=C3)=C3N4)=C4C=C2C5=CC=CC=C5)=O |
| 分子式 | C20H12N2O3 |
| 分子量 | 328.3 |
| 溶解度 | DMSO: 250 mg/mL (761.45 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PD 407824 is an inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively). It is selective for Chk1 and WEE1 over PKC (IC50 = 3.4 uM), Cdk4 (IC50 = 3.75 uM), as well as c-Src and the PDGF and FGF receptors (IC50s = >50 uM for all), and other Cdks (IC50s = >50 uM). PD 407824 sensitizes SK-OV-3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin when used at a concentration of 0.5 uM. It also sensitizes C2C12 myoblasts to bone morphogenic protein 4 (BMP4) and, when used in combination with BMP4, inhibits myotube formation and induces myoblasts to differentiate into mature osteoblasts. PD 407824, in combination with BMP4, induces human embryonic stem cells to differentiate into cells with mesoderm or cytotrophoblast stem cell lineages. |
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