L67 (DNA Ligase Inhibitor) 是一种竞争性 DNA 连接酶抑制剂，可有效抑制 DNA 连接酶 I/III（IC50 均为 10 μM）。 L67（DNA 连接酶抑制剂）可通过降低线粒体 DNA 水平和增加线粒体产生的 ROS 水平来引起核 DNA 损伤。 L67 (DNA Ligase Inhibitor) 还激活癌细胞中 Caspase 1 依赖性凋亡通路，可用于癌症研究。
| Cas No. | 325970-71-6 |
| 别名 | DNA Ligase Inhibitor |
| 化学名 | N-(3,5-dibromo-4-methylphenyl)-glycine, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide |
| Canonical SMILES | OC1=CC=C([N+]([O-])=O)C=C1/C=N/NC(CNC2=CC(Br)=C(C)C(Br)=C2)=O |
| 分子式 | C16H14Br2N4O4 |
| 分子量 | 486.1 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 uM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (Ki = 10 uM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 uM. |
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