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EIDD-2801
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EIDD-2801图片
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍

EIDD-2801 是核糖核苷类似物 EIDD-1931 的口服生物可利用的异丙酯前药。EIDD-2801 显示出广泛的抗流感病毒 (influenza virus) 和冠状病毒 (coronaviruses) 的活性,如?SARS-CoV-2,MERS-CoV,SARS-CoV。EIDD-2801 有用于 COVID-19 和季节性,流行性流感的潜力。

Animal Model:C57BL/6 mice (intranasal infection with SARS-CoV)[1]
Dosage:50, 150, 500 mg/kg
Administration:Oral; every 12 hours for 3 days
Result:Body weight loss is significantly diminished or prevented.
产品描述

EIDD-2801 is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. EIDD-2801 has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. EIDD-2801 has the potential for COVID-19, and seasonal and pandemic influenza treatment.

Reference:
[1]. Sheahan TP, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 Apr 6. pii: eabb5883.
[2]. Toots M, et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 2019 Oct 23;11(515). pii: eaax5866.