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Rupintrivir
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rupintrivir图片
CAS NO:223537-30-2
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Rupintrivirvr (AG7088) 是一种抗病毒药物,是一种强效、选择性和不可逆的人鼻病毒 (HRV) 3C 蛋白酶抑制剂。
Cas No.223537-30-2
别名(2E,4S)-4-[(2R,5S)-2-(4-氟苄基)-6-甲基-5-(5-甲基异恶唑-3-基甲酰氨基)-4-氧代庚酰氨基]-5-[[(3S)-2-氧代-3-吡咯烷基]-2-戊烯酸乙酯,AG7088
Canonical SMILESO=C(C1=NOC(C)=C1)N[C@@H](C(C)C)C(C[C@@H](CC2=CC=C(F)C=C2)C(N[C@H](/C=C/C(OCC)=O)C[C@@H]3CCNC3=O)=O)=O
分子式C31H39FN4O7
分子量598.66
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC50 = 5 nM). Exhibits no significant inhibition against a variety of serine and cysteine proteases. Inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays. products are for biomedical research use only. They are not intended for human or veterinary use.

Patick et al (1999) In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob.Agents Chemother. 43 2444 PMID:10508022 |Dragovich et al (1999) Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J.Med.Chem. 42 1203 PMID:10197964