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TH 1020
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TH 1020图片
CAS NO:1841460-82-9
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
TH 1020 是一种有效的选择性 toll 样受体 5 (TLR5)/鞭毛蛋白复合物拮抗剂,IC50 为 0.85 μM。
Cas No.1841460-82-9
Canonical SMILESN1(C(SC2=C3SC4=NC=CC=C4C3=NC=N2)=NN=C1C5=CC=NC=C5)CC6=CC=CC=C6
分子式C23H15N7S2
分子量453.54
溶解度Chloroform: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). Competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.

Yan et al (2016) Pyrimidine triazole thioether derivatives as toll-like receptor 5 (TLR5)/flagellin complex inhibitors. Chem.Med.Chem. 11 822 PMID:26634412