| CAS NO: | 117591-20-5 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Cas No. | 117591-20-5 |
| 化学名 | benzyl N-[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]carbamate |
| Canonical SMILES | CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 |
| 分子式 | C20H30N2O4 |
| 分子量 | 362.47 |
| 溶解度 | ≥ 87.6 mg/mL in DMSO, ≥ 96.6 mg/mL in EtOH |
| 储存条件 | Desiccate at 4℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 5 nM for human calpain 1 Calpeptin is a calpain inhibitor. As a calcium-dependent intracellular cysteine protease, calpain plays an key role in various cellular processes including cell differentiation, growth and apoptosis. In rheumatoid arthritis patients, over-expression of calpains are observed in arthritic synovial fluid and are thought to play critical roles in various cellular processes. In vitro: Calpeptin reduced production of TGF-b1, IL-6, angiopoietin-1 and collagen synthesis from lung fibroblasts. Calpeptin also reduced both angiopoietin-1-dependent migration and IL-6-dependent proliferation of the cells, which could be the underlying mechanism of the preventive effect of Calpeptin on pulmonary fibrosis [1]. In vivo: The preventive effect of calpeptin has been examined on bleomycin-induced pulmonary fibrosis in mice. Histological examinations and quantitative measurements of related proteins in bleomycin-treated mouse lung tissues with or without calpeptin were performed. Calpeptin histologically ameliorated bleomycininduced pulmonary fibrosis in mice. Results showed that calpeptin decreased the expression of IL-6, TGF-b1, angiopoietin-1 and collagen type Ia1 mRNA in mouse lung tissues [1]. Clinical trial: N/A Reference: |
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