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Kaempferide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kaempferide图片
CAS NO:491-54-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
Kaempferide 是一种 O-甲基化黄酮醇,一种化合物。
Cas No.491-54-3
别名山奈素; Kaempferol 4'-O-methyl ether
化学名3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one
Canonical SMILESCOC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
分子式C16H12O6
分子量300.26
溶解度DMF: 2mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL,Ethanol: 3mg/mL
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

The effects of phytoestrogens have been studied in the hypothalamic-pituitary-gonadal axis and various non-gonadal targets. Epidemiologic and experimental evidence indicates a protective effect of phytoestrogens also in colorectal cancer. The mechanism through which estrogenic molecules control colorectal cancer tumorigenesis could possibly involve estrogen receptor β, which is the predominantly expressed estrogen receptor subtype in colon mucosa.

In vitro: Kaempferide triglycoside proved to inhibit the proliferation of native and estrogen receptor β overexpressing colon cancer cells via a mechanism not mediated by ligand binding dependent estrogen receptor activation. It affected HCT8 cell cycle progression through increasing the G0/G1 cell fraction and in estrogen receptor β overexpressing cells increased two antioxidant enzymes [1].

In vivo: The aim of one previous study was to evaluate the effect of kaempferol on tissue lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal cancer in male Wistar rats and to compare its efficacy with irinotecan. This study revealed that kaempferol could be safely used as a chemopreventive agent in colorectal cancer [2].

Clinical trial: Up to now, kaempferide is still in the preclinical development stage.

Reference:
[1] Martineti V, Tognarini I, Azzari C, Carbonell Sala S, Clematis F, Dolci M, Lanzotti V, Tonelli F, Brandi ML, Curir P.  Inhibition of in vitro growth and arrest in the G0/G1 phase of HCT8 line human colon cancer cells by kaempferide triglycoside from Dianthus caryophyllus. Phytother Res. 2010 Sep;24(9):1302-8.
[2] Nirmala P, Ramanathan M.  Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats. Eur J Pharmacol. 2011 Mar 1;654(1):75-9.