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BIIL-260 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIIL-260 hydrochloride图片
CAS NO:192581-24-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
BIIL-260 hydrochloride 是一种有效的具口服活性白三烯 B(4) 受体 (LTB4) 的拮抗剂,有抗炎活性,是前药BIIL 284 的活性代谢产物。BIIL-260 hydrochloride 以可逆与竞争性方式与 LTB4 受体相互作用,对分离的人嗜中性粒细胞膜上的LTB4 受体具有高亲和力,Ki 值为 1.7 nM。
Cas No.192581-24-1
Canonical SMILESN=C(C1=CC=C(OCC2=CC=CC(COC3=CC=C(C(C)(C4=CC=C(O)C=C4)C)C=C3)=C2)C=C1)N.[H]Cl
分子式C30H31ClN2O3
分子量503.03
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM[1]. Ki: 1.7 nM (LTB4 receptor)[1]

BIIL-260 hydrochloride potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with IC50 value of 0.82 nM

[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.