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Angiotensin II 5-valine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Angiotensin II 5-valine图片
CAS NO:58-49-1
包装与价格:
包装价格(元)
10mM (in 1mL Water)电议
5mg电议
50mg电议
100mg电议

产品介绍

Angiotensin II 5-valine 是血管紧张素受体 (angiotensin receptor) 的激动剂。

Cas No.58-49-1
别名血管紧张素 Ⅱ 5-缬氨酸; Valine angiotensin II; 5-L-Valine angiotensin II
分子式C49H69N13O12
分子量1032.15
溶解度Water : ≥ 257.5 mg/mL (249.48 mM)
储存条件-20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Angiotensin II 5-valine is an agonist of angiotensin receptor. Angiotensin receptor[1].

By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1].

[1]. Zou LX et al. Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens. 1998 May;11(5):570-8.