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Alosetron((Z)-2-butenedioate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Alosetron((Z)-2-butenedioate)图片
CAS NO:122852-43-1
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
Alosetron (Z)-2-butenedioate (GR 68755 (Z)-2-butenedioate) 是5-HT3受体拮抗剂，可作用于肠易激综合征。
Cas No.122852-43-1
别名马来酸阿洛司琼; GR 68755 ((Z)-2-butenedioate); GR 68755X ((Z)-2-butenedioate)
Canonical SMILESO=C(C(C1=C2C=CC=C1)=C(N2C)CC3)N3CC4=C(NC=N4)C.O=C(/C=C\C(O)=O)O
分子式C21H22N4O5
分子量410.42
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Alosetron (Z)-2-butenedioate (GR 68755 (Z)-2-butenedioate) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.IC50 Value: N/ATarget: 5-HT ReceptorAlosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract. While being a 5-HT3 antagonist like ondansetron, it is not classified or approved as an antiemetic. Since stimulation of 5-HT3 receptors is positively correlated with gastrointestinal motility, alosetron's 5-HT3 antagonism slows the movement of fecal matter through the large intestine, increasing the extent to which water is absorbed, and decreasing the moisture and volume of the remaining waste products. From Wikipedia.

[1]. Bleser S.Alosetron for severe diarrhea-predominant irritable bowel syndrome: improving patient outcomes.Curr Med Res Opin. 2011 Mar;27(3):503-12. [2]. Lucak SL.Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome.Therap Adv Gastroenterol. 2010 May;3(3):165-72. [3]. Lewis JH.Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective.Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):13-29. [4]. Painsipp E, Shahbazian A, Holzer P.Alosetron, cilansetron and tegaserod modify mesenteric but not colonic blood flow in rats.Br J Pharmacol. 2009 Nov;158(5):1210-26. [5]. Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome By Spiller, Robin C.From Current Opinion in Pharmacology (2011), 11(1), 68-74.