Perlapine 是一种有效的毒蕈碱 DREADD（由 Designer Drugs 独家激活的 Designer Receptors）激动剂 Perlapine 对 hM3Dq 的选择性比 hM3 受体高 10000 倍以上。
| Cas No. | 1977-11-3 |
| 别名 | MP-11 |
| Canonical SMILES | CN(CC1)CCN1C2=NC(C=CC=C3)=C3CC4=C2C=CC=C4 |
| 分子式 | C19H21N3 |
| 分子量 | 291.4 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Perlapine is an atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively). Perlapine is also an agonist for hM3Dq, a designer receptor exclusively activated by designer drugs (DREADDs) derived from the human muscarinic acetylcholine M3 receptor that activates neuronal firing. Perlapine displays >10,000-fold selectivity for hM3Dq over hM3. |
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