β-Defensin-2(human)(trifluoroacetate salt)

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β-Defensin-2(human)(trifluoroacetate salt)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

β-Defensin-2(human)(trifluoroacetate salt)图片

包装:	100 μg
市场价:	4521元

产品介绍

An antimicrobial peptide

Canonical SMILES	[H]NCC(N[C@]([C@H](CC)C)([H])C(NCC(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@]([C@@H](C)O)([H])C4=O)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)CSSC[C@H](N6)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N7CCC[C@H]7C(O)=O)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)=O)CC9=CN=CN9)=O)CSSC[C@H](N4)C(NCC(N[C@@H](CC(C)C)C(N%10CCC[C@H]%10C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C%11=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)CSSC[C@H](N%11)C6=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O.FC(F)(C(O)=O)F
分子式	C₁₈₈H₃₀₅N₅₅O₅₀S₆• XCF₃COOH
分子量	0
溶解度	Water: 1 mg/ml
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.¹It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.²β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.³It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-2 induces IL-31 production by human peripheral blood-derived mast cellsin vitrowhen used at a concentration of 10 μg/ml and by rat mast cellsin vivofollowing a 500 ng intradermal dose.⁴Expression of β-defensin-2 is increased in psoriatic skin and chronic wounds.^5,6 1.Lehrer, R.I.Primate defensinsNat. Rev. Microbiol.2(9)727-738(2004) 2.Ouhara, K., Komatsuzawa, H., Yamada, S., et al.Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cellsJ. Antimicrob. Chemother.55(6)888-896(2005) 3.Niyonsaba, F., Ushio, H., Nakano, N., et al.Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokinesJ. Invest. Dermatol.127(3)594-604(2007) 4.Niyonsaba, F., Ushio, H., Hara, M., et al.Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cellsJ. Immunol.184(7)3526-3534(2010) 5.Huh, W.-K., Oono, T., Shirafuji, Y., et al.Dynamic alteration of human β-defensin 2 localization from cytoplasm to intercellular space in psoriatic skinJ. Mol. Med. (Berl.)80(10)678-684(2002) 6.Butmarc, J., Yufit, T., Carson, P., et al.Human β-defensin-2 expression is increased in chronic woundsWound Repair Regen.12(4)439-443(2004)