| CAS NO: | 1189923-38-3 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 1189923-38-3 |
| 别名 | 甲氧苄啶 D3 |
| Canonical SMILES | COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC([2H])([2H])[2H] |
| 分子式 | C14H15D3N4O3 |
| 分子量 | 293.3 |
| 溶解度 | DMSO: Slightly Soluble,Methanol: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Trimethoprim-d3is intended for use as an internal standard for the quantification of trimethoprim by GC- or LC-MS. Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid.1,2Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).2Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections. 1.Lam, T., Hilgers, M.T., Cunningham, M.L., et al.Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolinesJ. Med. Chem.57(3)651-668(2014) 2.Schweitzer, B.I., Dicker, A.P., and Bertino, J.R.Dihydrofolate reductase as a therapeutic targetFASEB J.4(8)2441-2452(1990) |
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