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STING Agonist 1a
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
STING Agonist 1a图片
CAS NO:652142-94-4
包装与价格：
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议

产品介绍
STING Agonist 1a (1a) 是干扰素基因 (STING) 激动剂的特异性刺激剂。
Cas No.652142-94-4
Canonical SMILESClC1=NC2=C(N3C1=NN=C3C4=C(Cl)N=C5C=CC(OC)=CC5=C4)C=CC=C2
分子式C19H11Cl2N5O
分子量396.2
溶解度DMF: slightly soluble,DMSO: slightly soluble,PBS (pH 7.2): slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 µM). STING agonist 1a (12.5-100 µM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .

1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screeningBioorg. Chem.100103958(2020)