CAS NO: | 59-53-0 |
包装 | 价格(元) |
250mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
Cas No. | 59-53-0 |
别名 | 乙酰青霉胺 |
Canonical SMILES | SC(C)(C)C(NC(C)=O)C(O)=O |
分子式 | C7H13NO3S |
分子量 | 191.2 |
溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml,Ethanol: 5 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | N-Acetyl-DL-penicillamine is a chelating agent.1,2,3It inhibits the binding of methyl mercury to isolated human erythrocytes by 50% and removes 50% of methyl mercury ions from methyl mercury-loaded blood cells when used at a concentration of 1 mM.1,2N-Acetyl-DL-penicillamine (3 mmol/kg per day, p.o.) reduces the biological half-life of mercury and decreases liver, kidney, brain, and blood mercury levels, as well as increases urinary excretion of mercury in a concentration-dependent manner, in mice when administered following injection of methyl mercuric chloride. It decreases mercuric chloride-induced mortality in mice when administered orally at a dose of 1.6 mmol/kg.3N-Acetyl-DL-penicillamine is also an analog of SNAP that does not generate nitric oxide and has been used as a negative control in experiments using SNAP.4,5 1.Aaseth, J.Mobilization of methyl mercury in vivo and in vitro using N-acetyl-DL-penicillamine and other complexing agentsActa Pharm. Toxicol. (Copenh.)39(3)289-301(1976) 2.Aaseth, J., Alexander, J., and Deverill, J.Evaluation of methyl mercury chelating agents using red blood cells and isolated hepatocytesChem. Biol. Interact.36(3)287-297(1981) 3.Nielsen, J.B., and Andersen, O.Effect of four thiol-containing chelators on disposition of orally administered mercuric chlorideHum. Exp. Toxicol.10(6)423-430(1991) 4.Ogura, T., DeGeorge, G., Tatemichi, M., et al.Suppression of anti-microtubule agent-induced apoptosis by nitric oxide: Possible mechanism of a new drug resistanceJpn. J. Cancer Res.89(2)199-205(1998) 5.Takhampunya, R., Padmanabhan, R., and Ubol, S.Antiviral action of nitric oxide on dengue virus type 2 replicationJ. Gen. Virol.87(Pt. 10)3003-3011(2006) |