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Nimesulide D5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nimesulide D5图片
CAS NO:1330180-22-7
包装:1mg
市场价:3600元

产品介绍
Nimesulide D5 是 Ethacrynic acid 的氘代物。Nimesulide 是一种有选择性的 COX-2 抑制剂,对其抑制具有时间依赖性,IC50 值为 70 nM-70 μM,但对 COX-1 的作用较弱 (IC50 >100 μM)。 Nimesulide 具有抗炎、止痛、解热的作用。
Cas No.1330180-22-7
别名尼美舒利 D5
Canonical SMILESCS(=O)(NC1=CC=C([N+]([O-])=O)C=C1OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O
分子式C13H7D5N2O5S
分子量313.34
溶解度Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties[1][2].

[1]. Vago T, et al. Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity. Arzneimittelforschung. 1995 Oct;45(10):1096-8. [2]. Werner MF, et al. Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. Eur J Pharmacol. 2006 Aug 14;543(1-3):181-9.