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JNJ 39758979 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JNJ 39758979 dihydrochloride图片
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
High affinity and selective histamine H4 antagonist; orally bioavailable
Canonical SMILESCC(C1=CC(N2CC[C@H](C2)N)=NC(N)=N1)C.Cl.Cl
分子式C11H19N5.2HCl
分子量294.22
溶解度Soluble in DMSO
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

High affinity and selective histamine H4 antagonist (Ki = 12.5 nM). Exhibits >80-fold selectivity for H4 over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.

Thurmond et al (2014) Clinical and preclinical characterization of the histamine H4 receptor antagonist JNJ-39758979. J.Pharmacol.Exp.Ther. 349 176 PMID:24549371