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HS 38
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
HS 38图片
CAS NO:1030203-81-6
包装:5mg
市场价:1176元

产品介绍
HS 38 是一种有效的、选择性的和 ATP 竞争性的死亡相关蛋白激酶 1 (DAPK1) 和拉链相互作用蛋白激酶 (ZIPK，也称为 DAPK3) 抑制剂，Kd 值分别为 300 nM 和 280 nM。
Cas No.1030203-81-6
Canonical SMILESO=C1NC(SC(C(N)=O)C)=NC2=C1C=NN2C3=CC=CC(Cl)=C3
分子式C14H12CIN5O2S
分子量349.8
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ATP-competitive inhibitor of DAPK (IC50 = 200 nM) and ZIPK (Kd = 280 nM). Also inhibits PIM3 kinase (IC50 = 200 nM) but exhibits no significant effect on Src or Abl kinases. Reduces phosphorylation of regulatory myosin light chain and myosin light chain phosphatase in mouse aortic and rabbit ileal tissues.

MacDonald et al (2016) A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. Mol.Pharmacol. 89 105 PMID:26464323 |Carlson et al (2013) Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. ACS.Chem.Biol. 8 2715 PMID:24070067