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Phenelzine-d5(sulfate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phenelzine-d5(sulfate)图片
CAS NO:1219798-40-9
包装与价格:
包装价格(元)
500μg电议
1mg电议

产品介绍
An internal standard for the quantification of phenelzine
Cas No.1219798-40-9
别名硫酸苯乙肼 d5 (硫酸盐)
Canonical SMILESNNCCC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H].O=S(O)(O)=O
分子式C8H7D5N2• H2SO4
分子量239.3
溶解度DMSO: soluble,Methanol: soluble,Water: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Phenelzine-d5 (sulfate) is intended for use as an internal standard for the quantification of phenelzine by GC- or LC-MS. Phenelzine is an inhibitor of monoamine oxidase (MAO; IC50 = 0.9 μM using rat brain mitochondrial preparations).1 It potentiates the effects of tryptamine on isolated rat fundus (EC50 = 90 nM) and increases tryptamine toxicity in mice with LD50 values of 85 and 500 mg/kg in the presence and absence of phenelzine, respectively. Phenelzine (20 mg/kg) increases GABA, dopamine, serotonin , and norepinephrine levels in the hippocampus and cortex of socially isolated rats and rats treated with the NMDA receptor antagonist (+)-MK-801 .2 It also increases 5-HT levels in the ventral horn of the spinal cord, improves gross motor ability in a rotarod test, and increases locomotor activity in an open field test in mice with experimental autoimmune encephalomyelitis when administered at a dose of 30 mg/kg.3