您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Oxcarbazepine-d4
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Oxcarbazepine-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oxcarbazepine-d4图片
CAS NO:1134188-71-8
包装:1mg
市场价:2948元

产品介绍
奥卡西平-d4 是氘标记的奥卡西平。
Cas No.1134188-71-8
别名奥卡西平-D4,GP 47680-D4
Canonical SMILESO=C1C2=C(C([2H])=C([2H])C([2H])=C2[2H])N(C(N)=O)C3=C(C=CC=C3)C1
分子式C15H8D4N2O2
分子量256.3
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Oxcarbazepine-d4 is intended for use as an internal standard for the quantification of oxcarbazepine by GC- or LC-MS. Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine .1,2 It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 μM.2 Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50s = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole or picrotoxin in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.

|1. AmbrÓsio, A.F., Soares-Da-Silva, P., Carvalho, C.M., et al. Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem. Res. 27(1-2), 121-130 (2002).|2. McLean, M.J., Schmutz, M., Wamil, A.W., et al. Oxcarbazepine: Mechanisms of action. Epilepsia 35(Suppl. 3), S5-S9 (1994).