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Sphingosine-1-phosphate-d7(d18:1)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sphingosine-1-phosphate-d7(d18:1)图片
CAS NO:2260670-15-1
包装与价格:
包装价格(元)
500μg电议
1mg电议

产品介绍
An internal standard for the quantification of S1P
Cas No.2260670-15-1
别名鞘氨醇-1-磷酸酯-D7(D18:1),S1P-d7 (d18:1), Sphingosine-1-Phosphoric Acid-d7
化学名(2S,3R,4E)-2-amino-4-octadecene-16,16,17,17,18,18,18-d7-1,3-diol, 1-(dihydrogen phosphate)
Canonical SMILESO[C@H](/C=C/CCCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[C@@H](N)COP(O)(O)=O
分子式C18H31D7NO5P
分子量386.5
溶解度0.3 M NaOH: 4 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sphingosine-1-phosphate-d7 is intended for use as an internal standard for the quantification of sphingosine-1-phosphate by GC- or LC-MS. S1P is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors.[1] It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively).[2] Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity.[3] S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.

Reference:
[1]. Sanchez, T., and Hla, T. Structural and functional characteristics of S1P receptors. J. Cell. Biochem. 92(5), 913-922 (2004).
[2]. An, S., Bleu, T., and Zheng, Y. Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors. Mol. Pharmacol. 55(5), 787-794 (1999).
[3]. Cartier, A., and Hla, T. Sphingosine 1-phosphate: Lipid signaling in pathology and therapy. Science 366(6463), (2019).