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UK51656
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UK51656图片
CAS NO:88150-59-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
UK51656是一种calcium拮抗剂,IC50值为4nM。
Cas No.88150-59-8
Canonical SMILESO=C(C(C(C(C=CC=C1)=C1Cl)C(C(OC)=O)=C(C)N2)=C2COCCNCC(N)=O)OCC
分子式C22H28ClN3O6
分子量465.93
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

UK51656 is a calcium antagonist with IC50 of 4 nM.

UK51656 has an elimination half-life of 4.7 h, which is consistent with its duration of action in the anesthetized dog. The effect of UK51656 on coronary vascular resistance, has markedly long durations, being over 5 h[1].

[1]. Alker D, et al. Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2-[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists. J Med Chem. 1990 Feb;33(2):585-91.