Rimeporide hydrochloride(EMD-87580 hydrochloride)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

187870-95-7

包装与价格：

产品介绍

Rimeporide hydrochloride (EMD-87580 hydrochloride) (EMD-87580 hydrochloride) 是 Na+/H+ 交换剂 (NHE-1) 的有效选择性抑制剂。

Cas No.	187870-95-7
别名	EMD-87580 hydrochloride
Canonical SMILES	O=C(NC(N)=N)C1=CC(S(=O)(C)=O)=C(S(=O)(C)=O)C=C1C.Cl
分子式	C₁₁H₁₆ClN₃O₅S₂
分子量	369.84
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1). Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent[1]. [1]. F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.