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(-)-(S)-B-973B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(-)-(S)-B-973B图片
CAS NO:2244989-34-0
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
(-)-(S)-B-973B为一种有效的α7nAChR别构激动剂和正别构调节剂,具有镇痛作用。
Cas No.2244989-34-0
Canonical SMILESO=C(N[C@H](C1=NC(N2CCN(C3=NC=CC=C3)CC2)=CN=C1)C)CCC4=CC=C(F)C(F)=C4
分子式C24H26F2N6O
分子量452.5
溶解度DMSO : 67.5 mg/mL (149.17 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(-)-(S)-B-973B is a potent allosteric agonism and positive allosteric modulation (ago-PAM) for α7 nAChR, with antinociceptive activity[1].

[1]. Garai S, et al. B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation. ACS Med Chem Lett. 2018 Oct 11;9(11):1144-1148.