PF 3084014 hydrobromide

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1962925-29-6

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议

产品介绍

PF 3084014 hydrobromide (PF-3084014 dihydrobromide) 是一种可逆的、可口服的、非竞争性的、选择性的 γ-secretase 抑制剂，IC50 为 6.2 nM。通过 PF 3084014 氢溴酸盐抑制 Notch 信号传导，同时最大限度地减少胃肠道毒性，为研究 Notch 受体依赖性癌症提供了一种有前途的方法。

Cas No.	1962925-29-6
别名	PF-3084014 dihydrobromide; PF-03084014 dihydrobromide
Canonical SMILES	O=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br
分子式	C₂₇H₄₁F₂N₅O.2HBr
分子量	651.47
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs. Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID:20363853