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Tropolone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tropolone图片
CAS NO:533-75-5
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
250mg电议

产品介绍
Tropolone 是一种在 2 位具有羟基的 tropone 衍生物，是许多azulene 衍生物的前体，例如 2-methylazulene-1-carboxylate 。
Cas No.533-75-5
别名环庚三烯酚酮
Canonical SMILESOC1=CC=CC=CC1=O
分子式C7H6O2
分子量122.1
溶解度DMF: 5mg/mL,DMSO: 10mg/mL,Ethanol: 30mg/mL,Ethanol:PBS (pH 7.2) (1:6): 0.14mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities.1,2,3,4,5 It inhibits catechol O-methyltransferase (COMT; Ki = 22 μM).1 Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 μM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM.2 It is an iron chelator that inhibits iron-dependent growth of the wood rot fungus P. placenta when used at a concentration of 50 μM and P. placenta degradation of pine sapwood blocks impregnated with 5 mM tropolone.3 It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 μM).4 Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats.5 Dietary administration of tropolone induces growth retardation and hyperactivity in mice.

|1. Borchardt, R.T. Catechol 0-methyltransferase. 1. Kinetics of tropolone inhibition. J. Med. Chem. 16(4), 377-382 (1973).|2. Trust, T.J. Antibacterial activity of tropolone. Antimicrob. Agents Chemother. 7(5), 500-506 (1975).|3. Diouf, P.N., Delbarre, N., Perrin, D., et al. Influence of tropolone on Poria placenta wood degradation. Appl. Environ. Microbiol. 68(9), 4377-4382 (2002).|4. Nishishiro, M., Kurihara, T., Wakabayashi, H., et al. Effect of tropolone, azulene and azulenequinone derivatives on prostaglandin E2 production by activated macrophage-like cells. Anticancer Res. 29(1), 379-383 (2009).|5. Lee, C.P., Hegarty, M.P., and Christie, G.S. Antithyroid and antiperoxidase activity of tropolone and 3-hydroxy-4-pyrone. Chem. Biol. Interact. 27(1), 17-26 (1979).