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C22 Ceramide(d18:1/22:0)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
C22 Ceramide(d18:1/22:0)图片
CAS NO:27888-44-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍

C-22 ceramide is an endogenous bioactive sphingolipid.

Cas No.27888-44-4
别名C22 Ceramide；Cer(d18:1/22:0)；Ceramide (d18:1/22:0)
化学名N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-docosanamide
Canonical SMILESOC[C@H](NC(CCCCCCCCCCCCCCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCCCC
分子式C40H79NO3
分子量622.1
溶解度0.15mg/ml in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

C-22 ceramide is an endogenous bioactive sphingolipid. Ceramides are involved in permeabilization of the mitochondrial outer membrane during apoptosis via the intrinsic pathway.[1] C-22 ceramide forms small channels in liposomes, whereas C-16 ceramide forms channels that can grow in size, suggesting that acyl chain length of ceramides is important in mitochondrial-mediated apoptosis. In addition, the mitochondrial-to-cytosolic stress response (MCSR) in C. elegans fed C-22 ceramide decreases following inhibition of Hsp6 (mortalin/Grp75/mtHsp70) using RNAi.[2]

Reference:
[1]. Stiban, J., and Perera, M. Very long chain ceramides interfere with C16-ceramide-induced channel formation: A plausible mechanism for regulating the initiation of intrinsic apoptosis. Biochim. Biophys. Acta 1848(2), 561-567 (2015).
[2]. Kim, H.E., Grant, A.R., Simic, M.S., et al. Lipid biosynthesis coordinates a mitochondrial-to-cytosolic stress response. Cell 166(6), 1539-1552 (2016).