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C16 Ceramide(d18:1/16:0)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
C16 Ceramide(d18:1/16:0)图片
CAS NO:24696-26-2
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Cas No.24696-26-2
别名N-棕榈酰神经鞘氨醇,Palmitoyl Ceramide
化学名N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-hexadecanamide
Canonical SMILESCCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC(CCCCCCCCCCCCCCC)=O)CO
分子式C34H67NO3
分子量537.9
溶解度0.5mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway, which requires coordinate action of serine palmitoyl transferase and ceramide synthase. They have been shown to mediate antiproliferative responses such as apoptosis, growth arrest, differentiation, and senescence.[1] C16 ceramide (d18:1/16:0) is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling. [2] Accumulation of C16 ceramide (d18:1/16:0) through PPMP (30 μM) or MAPP (50 μM) treatment or from addition of 100 μM synthetic C16 ceramide (d18:1/16:0) induces apoptosis in neutrophil cultures via caspase-3 activation.[3]

Reference:
[1]. Ogretmen, B., Pettus, B.J., Rossi, M.J., et al. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A547 human lung adenocarcinoma cell line. J. Biol. Chem. 277(15), 12960-12969 (2002).
[2]. White-Gilbertson, S., Mullen, T., Senkal, C., et al. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells. Oncogene 28(8), 1132-1141 (2009).
[3]. Seumois, G., Fillet, M., Gillet, L., et al. De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis. J. Leukoc. Biol. 81(6), 1477-1486 (2007).