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Thiolutin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Thiolutin图片
CAS NO:87-11-6
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Thiolutin (Acetopyrrothin) 是一种由链霉菌产生的含二硫化物的抗生素和抗血管生成化合物。
Cas No.87-11-6
别名硫藤黄素,Acetopyrrothin
化学名N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide
Canonical SMILESCC(=O)NC1=C2C(=CSS2)N(C1=O)C
分子式C8H8N2O2S2
分子量228.28
溶解度DMF: 0.5 mg/ml,DMSO: 1 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
储存条件Desiccate at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36[1]. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation[2].

References:
[1]. Lauinger L, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol. 2017 Jul;13(7):709-714.
[2]. Jia Y, et al. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress Chaperones. 2010 Mar;15(2):165-81.