Alexidine dihydrochloride 是一种抗癌剂，可靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶 PTPMT1，并导致线粒体凋亡。
| Cas No. | 1715-30-6 |
| 别名 | 己联双辛胍二盐酸盐 |
| 化学名 | 1-[N'-[6-[[amino-[[N'-(2-ethylhexyl)carbamimidoyl]amino]methylidene]amino]hexyl]carbamimidoyl]-2-(2-ethylhexyl)guanidine;dihydrochloride |
| Canonical SMILES | CCCCC(CC)CN=C(N)NC(=NCCCCCCN=C(N)NC(=NCC(CC)CCCC)N)N.Cl.Cl |
| 分子式 | C26H56N10.2HCl |
| 分子量 | 581.71 |
| 溶解度 | ≥ 14.8mg/mL in DMSO, ≥ 25.85 mg/mL in EtOH with gentle warming |
| 储存条件 | Desiccate at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50= 1.08 μMin vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. |
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