EB 47 是一种有效的选择性 PARP-1/ARTD-1 抑制剂，IC50 值为 45 nM，对 ARTD5 显示出适度的效力，IC50 值为 410 nM。
| Cas No. | 1190332-25-2 |
| 化学名 | 2-(4-((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-carbonyl)piperazin-1-yl)-N-(1-oxoisoindolin-4-yl)acetamide dihydrochloride |
| Canonical SMILES | O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1C(N4CCN(CC(NC5=CC=CC6=C5CNC6=O)=O)CC4)=O.Cl.Cl |
| 分子式 | C24H27N9O6.2HCl |
| 分子量 | 610.45 |
| 溶解度 | <30.52mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | EB 47 is a potent inhibitor of PARP-1 with IC50 of 45 nM. |
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