CAS NO: | 3565-26-2 |
包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
25mg | 电议 |
50mg | 电议 |
Cas No. | 3565-26-2 |
别名 | 8-羟基-5-硝基喹啉 |
化学名 | 5-nitrosoquinolin-8-ol |
Canonical SMILES | C1=CC2=C(C=CC(=C2N=C1)O)N=O |
分子式 | C9H6N2O2 |
分子量 | 174.16 |
溶解度 | ≥ 7.35mg/mL in DMSO |
储存条件 | Store at RT |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | NSC 3852 is a potent inhibitor of histone deacetylase [1]. Histone deacetylases (HADC) are a series of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone and make the histones to wrap the DNA more tightly, which prevent transcription. In MCF-7 human breast cancer cells, NSC 3852 induced the formation of the DMPO-OH adduct, which was catalyzed by superoxide dismutase. The result suggested that NSC 3852 induced generation of superoxide and reactive oxygen species (ROS), which produced DNA damage and induced apoptosis. Also, NSC 3852 resulted in cells accumulation in G0, hypophosphorylated retinoblastoma protein(Rb) and reduced E2F1 and Myc protein [1]. In HS68 cell, NSC 3852 inhibited Toxoplasma gondii tachyzoite propagation with EC50 value of 78.6 nM. Also, in human red blood cells, NSC 3852 inhibited Plasmodium falciparum growth with EC50 value of 1.3 μM. NSC 3852 inhibited Toxoplasma gondii tachyzoite propagation by involving redox reactions [2]. References: |