包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
Canonical SMILES | COC1=CC2=CC=CC=C2C(NC3=CC=CC(C(OCC)=O)=C3)=C1 |
分子式 | C20H19NO3 |
分子量 | 321.37 |
溶解度 | DMSO: 100 mg/mL (311.17 mM); Ethanol: 50 mg/mL (155.58 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | CDC25B-IN-1 (compound 4a) is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase, with a Ki of 8.5 μM. CDC25B-IN-1 potently inhibits cell proliferation and colony formation, causes an increase of the G2/M phase[1]. Ki: 8.5 μM (CDC25B phosphatase)[1] [1]. Cerchia C, et al. Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines. J Med Chem. 2019 Aug 8;62(15):7089-7110. |